description
Hereditary haemochromatosis is a genetic disease that causes the body to absorb too much iron from food eaten. Excess iron is stored in body organs, especially the liver, heart and pancreas.
Damage to organs caused by too much iron is stored causes life-threatening disorders such as cancer, heart disease, and liver.
Haemochromatosis, When the Body Absorb Iron Most
symptom
Early signs and symptoms of hereditary haemochromatosis-like symptoms of other common diseases, making it difficult to diagnose. Signs and symptoms include:
1. fatigue
2. Loss of sex drive (libido) or impotence
3. Lack of normal menstruation (amenorrhea)
4. Pain in the upper right abdomen
Some patients with hereditary haemochromatosis have no symptoms, while others experience a variety of problems. These symptoms vary in individuals and may be different for men and women.
Although hereditary haemochromatosis has been there since birth, most people do not experience signs and symptoms until later in life, usually between ages 30 to 50 years in men and after age 50 years in women. Women generally experience symptoms after menopause, when no longer lose iron through menstruation and pregnancy.
cause
Hereditary haemochromatosis is caused by mutations of genes that control the amount of iron absorbed from food. Mutations that cause hereditary haemochromatosis inherited from parents to their children.
The gene that is mutated in patients with hereditary haemochromatosis called HFE. A child inherits one gene from each parent HFE. If both parents pass the mutated HFE gene to her child, the child may be suffering from haemochromatosis.
HFE gene has two common mutations, C282Y and H63D. Genetic testing can reveal whether someone has a mutation in the HFE gene or not.
Haemochromatosis, When the Body Absorb Iron Most
If a person inherits two abnormal genes, it can develop haemochromatosis, but not all people with two abnormal genes have signs and symptoms of haemochromatosis.
If a person inherits an abnormal gene, he will not have haemochromatosis. But the body may absorb more iron than normal. He is considered to be carriers of gene mutations and these mutations can be passed down to their children.
